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Antianginals | PDE5 inhibitors

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Vasodilation is where blood vessels in the body become wider following the relaxation of the smooth muscle in the vessel wall. This will reduce blood pressure - since there is more room for the blood. The opposite physiological process is vasoconstriction.

Vasomotor refers to the muscles and nerves controlling the process of vasodilation.

A vasodilator is a substance that causes vasodilation. Several vasodilators are used as drugs which may, for example, allow blood to flow more easily around a clot.

Flushing may be a physiological response to vasodilators.

Natural vasodilators and Drugs that Exploit Them

  • Absence of high levels of environmental noise
  • Adenosine
    • Adenocard - this is primarily used as an anti-arrhythmic.
  • Adrenaline and noradrenaline vasodilate arterioles of the skeletal muscles. (By acting on beta-2 adrenergic receptors.) These chemicals cause vasoconstriction elsewhere.
  • L-Arginine
    Atrial natriuretic peptide (ANP) - a weak vasodilator.
    Endothelium-derived hyperpolarizing factor (EDHF)
  • Histamine
    • Complement proteins C3a, C4a and C5a work by triggering histamine release from mast cells and basophil granulocytes.
  • Niacin (aka nicotinic acid)
  • Nitric oxide
    • Glyceryl trinitrate (commonly known as Nitroglycerin)
      Isosorbide mononitrate & Isosorbide dinitrate
      Pentaerythritol Tetranitrate (PETN)
      Sodium nitroprusside
    • PDE5 inhibitors: these agents indirectly increase the effects of nitric oxide
  • Platelet activating factor (PAF)
    Prostacyclin (PGI2) as well as other prostaglandins.
  • Tetrahydrocannabinol (THC) - the major active chemical in marijuana. Its mild vasodilating effects redden the eyes of cannabis smokers.
  • Papaverine an alkaloid found in the opium poppy papaver somniferum

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This guide is licensed under the GNU Free Documentation License. It uses material from the Wikipedia.