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Reversible inhibitors of MAO-A

Drugs & Medication

Reversible inhibitors of MAO-A

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RIMAs (reversible inhibitors of monoamine oxidase type-A) are a family of psychiatric drugs that inhibit monoamine oxidase, temporarily and reversibly. They are mostly used for alleviating depression and dysthymia.

Because their action is short-lived and selective, they have a better safety profile than the older MAOI drugs (monoamine oxidase inhibitors). A special diet does not need to be so strictly adhered to, although eating excessively large amounts of tyramine-containing foods is not advisable.

Combining a RIMA or MAOI with an SSRI is dangerous since it can lead to serotonin syndrome and possible fatality.

Moclobemide and Brofaromine are RIMAs.

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