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Piroxicam chemical structure
Systematic (IUPAC) name
9-(hydroxy-pyridin-2-ylamino-methylidene)- 8-methyl-7,7-dioxo-7$l^{6}-thia-8-azabicyclo[ 4.4.0] deca-1,3,5-trien-10-one
CAS number 36322-90-4
ATC code M01AC01 M02AA07, S01BC06
PubChem 5280452
DrugBank APRD01187
Chemical data
Formula C15H13N3O4S
Mol. weight 331.348 g/mol
Pharmacokinetic data
Metabolism 4-10% renal
Half life 30 to 86 hours
Excretion 4-10% renal
Therapeutic considerations
Pregnancy cat. C, D if used in the third trimester or near delivery

Piroxicam (US trade name Feldene) is a nonsteroidal anti-inflammatory drug used to relieve the symptoms of arthritis, primary dysmenorrhoea, pyrexia; and as an analgesic, especially where there is an inflammatory component. It is also used in veterinary medicine to treat certain neoplasias expressing cyclooxygenase (COX) receptors, such as bladder, colon, and prostate cancers.

Mechanism of action

Piroxicam is an NSAID and, as such, is a non-selective COX inhibitor possessing both analgesic and antipyretic properties.

Adverse effects

Piroxicam use can result in gastrointestinal toxicity, tinnitus, dizziness, headache, rash, and pruritus. The most severe adverse reactions are peptic ulceration and gastrointestinal bleeding. Approximately 30% of all patients receiving daily doses of 20 mg of piroxicam experience side effects.[1]


  1. ^ New Zealand Medicines and Medical Devices Safety Authority. Candyl Medicines datasheet. Retrieved on 2006-09-10.

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