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Lincosamide antibiotics

Drugs & Medication

Lincosamide antibiotics

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Lincosamides (eg. lincomycin, clindamycin) are a class of drugs which bind to 50S subunit of bacterial ribosomes and inhibit early elongation of peptide chain by inhibiting transpeptidase reaction. In this sense they have a similar action to macrolides.


Target bacteria may alter the drug's target site (similar to resistance found in macrolides and streptogramins). Also, enzymatic inactivation of clindamycin has been described (rare).


These are bacteriostatic drugs and antagonists of macrolides and streptogramins.

Further reading

  • Van Bambeke F. Mechanisms of action. In Armstrong D, Cohen J. Infectious diseases. Mosby, London, 1999, pp7/1.1-7/1.14

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