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Lansoprazole (Prevacid)

Drugs & Medication

Lansoprazole (Prevacid)

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Lansoprazole chemical structure
Systematic (IUPAC) name
2-[(3-methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl) methylsulfinyl] -1H-benzoimidazole
CAS number 103577-45-3
ATC code A02BC03
PubChem 3883
DrugBank APRD00077
Chemical data
Formula C16H14N3F3OS 
Mol. weight 369.363 g/mol
Pharmacokinetic data
Bioavailability 80% or more
Metabolism Hepatic (CYP3A4- and CYP2C19-mediated)
Half life 1 - 1.5 hours
Excretion Renal and fecal
Therapeutic considerations
Licence data US
Pregnancy cat. B3(AU) B(US)
Legal status Prescription only
Routes Oral, IV

Lansoprazole (lan-SOE-pra-zole, INN) is a proton pump inhibitor which prevents the stomach from producing acid.



Lansoprazole is a proton pump inhibitor (PPI) similar to omeprazole. Lansoprazole's plasma elimination half-life is not proportional to the duration of the drug's effects (i.e. gastric acid suppression). The plasma elimination half-life is 1.5 hours or less, and the effects of the drug last for over 24 hours after it has been used for 5 days or more.


Lansoprazole is indicated for:

  • Treatment of ulcers of the stomach and duodenum, and NSAID-induced ulcers
    Treatment of gastroesophageal reflux disease (GERD) (also known as acid reflux disease)
    Treatment of Zollinger-Ellison Syndrome
    Treatment of Barrett's esophagus
    Adjunctive treatment of Helicobacter pylori infection, alongside antibiotics


  • Absorption of lansoprazole is reduced by antacids.
  • PPI’s reduce absorption of antifungals (itraconazole and ketoconazole) and possibly increase Digoxin in plasma
  • Increases plasma concentrations of Cilostazol (risk of toxicity)
  • Absorption of lansoprazole possibly reduced by:
    • sucralfate
    • ampicillin
    • bisacodyl
    • iron salts
    • theophylline
    • voriconazole
      aminophylline and theophylline

Side effects

  • Infrequent: dry mouth, insomnia, drowsiness, blurred vision, rash, pruritus
  • Rarely and very rarely: taste disturbance, liver dysfunction, peripheral oedema, hypersensitivity reactions (including bronchospasm, urinary, angioedema, anaphylaxis), photosensitivity, fever, sweating, depression, interstitial nephritis, blood disorders (including leukopenia, leukocytosis, pancytopenia, thrombocytopenia), arthralgia, myalgia, skin reactions (including Stevens-Johnson syndrome, toxic epidermal necrolysis, bullous eruption)
  • Increases the risk of gastric-intestinal infections by reducing gastric acidity.
  • Severe: Gastro-intestinal disturbances (such as nausea, vomiting, abdominal pain, flatulence, diarrhea, constipation), headache, dizziness

Brand names

The drug is sold with the following brand names:

  • Lansox® (Italy)
  • Limpidex® (Italy)
  • Prevacid® (U.S. and Canada)
  • Takepron® (Japan)
  • Zoton® (Italy)

Lansoprazole is also available as a generic drug in Italy.

External links

Home | Up | Esomeprazole (Nexium) | Lansoprazole (Prevacid)

Drugs & Medication, made by MultiMedia | Free content and software

This guide is licensed under the GNU Free Documentation License. It uses material from the Wikipedia.

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