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Glycopeptide antibiotics

Drugs & Medication

Glycopeptide antibiotics

Vancomycin

From Wikipedia the free encyclopedia, by MultiMedia

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Glycopeptide antibiotics are a class of antibiotic drugs. They consist of a glycosylated cyclic or polycyclic nonribosomal peptide. Important glycopeptide antibiotics include vancomycin, teicoplanin, ramoplanin, and decaplanin.

This class of drugs inhibit the synthesis of cell walls in susceptible microbes by inhibiting peptidoglycan synthesis. Due to their toxicity, their use is restricted to those patients who are critically ill or who have a demonstrated hypersensitivity to the β-lactams. Principally effective against gram positive cocci, they exhibit a narrow spectrum of action. They are the last effective line of defense for cases of Methicillin-resistant Staphylococcus aureus.

Vancomycin is usually given intravenously and can cause tissue necrosis and phlebitis at the injection site if given too rapidly. Indeed pain at site of injection is a common adverse event.


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Drugs & Medication, made by MultiMedia | Free content and software

This guide is licensed under the GNU Free Documentation License. It uses material from the Wikipedia.


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