Niche it!
BobbyGs Info

Microsoft Store

Doxycycline

Drugs & Medication

Doxycycline

From Wikipedia the free encyclopedia, by MultiMedia

Home | Up | Next


Doxycycline chemical structure
Doxycycline
Systematic (IUPAC) name
(2-(amino-hydroxy-methylidene)-4-dimethylamino

-5,10,11,12a-tetrahydroxy-6-methyl- 4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

Identifiers
CAS number 564-25-0
ATC code J01AA02
PubChem 11256
DrugBank APRD00597
Chemical data
Formula C22H24N2O8 
Mol. weight 444.435 g/mol
Pharmacokinetic data
Bioavailability 100%
Metabolism hepatic
Half life 18-22 hours
Excretion urine, feces
Therapeutic considerations
Pregnancy cat. D(US)
Legal status POM(UK) -only(US)
Routes oral, periodontal, iv, im

Doxycycline (INN) (IPA: [ ˌdɒksɪˈsaɪklin ]) is a member of the tetracycline antibiotics group and is commonly used to treat a variety of infections. Brand names include Monodox®, Periostat®, Vibramycin®, Vibra-Tabs®, Doryx®, Vibrox®, Adoxa®, Doxyhexal® and Atridox® (topical doxycycline hyclate for gum disease).

Contents

Indicated uses

As well as the general indications for all members of the tetracycline antibiotics group, Doxycycline is frequently used to treat chronic prostatitis, sinusitis, syphilis, chlamydia, pelvic inflammatory disease, acne and rosacea. In addition it is used in the treatment and prophylaxis of Bacillus anthracis (anthrax) and malaria. Its mechanism of action against malaria is to specifically impair in the progeny the apicoplast genes resulting in their abnormal cell division.[1]

It is also effective against Yersinia pestis (the infectious agent of bubonic plague) and is prescribed for the treatment of Lyme disease and Rocky Mountain spotted fever.

Elephantiasis is a disease caused by a nematode (worm) Wuchereria bancrofti. It causes swollen limbs and genitals (Filariasis) and affects over 120 million people in the world. Previous anti-nematode treatments have been limited by poor levels of effectiveness, drug side effects and high costs. Doxycycyline was shown in 2003 to kill the symbiotic Wolbachia bacteria upon which the nematodes are dependent.[2] Field trials in 2005 showed that Doxycycline almost completely eliminates blood-borne filaria when given for an 8 week course.[3][4]

Cautions and Side effects

Are as for other members of the tetracycline antibiotics group. However the 10% risk of photosensitivity skin reactions is of particular importance for those intending long-term use for malaria prophylaxis. Reports of GERD have been cited with the use of Doxycycline.

Unlike some other members of the group, it may be used in those with renal impairment.

Doxycycline impairs the effectiveness of many types of contraceptive pill and physicians recommend the use of barrier contraception for people taking the drug to prevent unwanted pregnancy. Contrary to popular belief, the drug does not cause patients to exhibit side-effects preventing other forms of sexual activity such as oral or anal sex.

It should be taken with a full glass of water to prevent irritation of the esophagus or stomach.

Experimental applications

At subantimicrobial doses, doxycycline is an inhibitor of matrix metalloproteinases, and has been used in various experimental systems for this purpose. Doxycycline has been used successfully in the treatment of one patient with lymphangioleiomyomatosis, an otherwise progressive and fatal disease.[5]

Doxycycline has also been used to regulate transgene expression in mice using the Tet-on gene control system.

References and notes

  1. ^ Dahl E, Shock J, Shenai B, Gut J, DeRisi J, Rosenthal P (Sep 2006). "Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum.". Antimicrob Agents Chemother 50 (9): 3124-31. PMID 16940111.
  2. ^ Hoerauf A, Mand S, Fischer K, Kruppa T, Marfo-Debrekyei Y, Debrah AY, Pfarr KM, Adjei O, Buttner DW (2003). "Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production". Med Microbiol Immunol (Berl) 192 (4): 211-6. PMID 12684759.
  3. ^ Taylor MJ, Makunde WH, McGarry HF, Turner JD, Mand S, Hoerauf A (2005). "Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial". Lancet 365 (9477): 2116-21. PMID 15964448.
  4. ^ Outland, Katrina. "New Treatment for Elephantitis: Antibiotics", The Journal of Young Investigators, 2005 Volume 13.
  5. ^ Moses MA, Harper J, Folkman J (2006). "Doxycycline treatment for lymphangioleiomyomatosis with urinary monitoring for MMPs". N Engl J Med 354 (24): 2621–22.
  • British National Formulary 45 March 2003

External link

  • Atridox website - A novel topically applied form of doxycycline hyclate for treatment of periodontitis

Home | Up | Doxycycline | Tetracycline

Drugs & Medication, made by MultiMedia | Free content and software

This guide is licensed under the GNU Free Documentation License. It uses material from the Wikipedia.


Sony Creative Software Inc.

Music Videos
Languages
Select Interface Language:

English French German Hungarian Italian Norwegian Spanish
Shopping Random Product
Shopping Search

Emporium Contents
Gallery Most Viewed
Gallery Most Viewed
Recommended Software Sites

Montego Scripts - Home of HTML Newsletter

Code-Authors.com

nukeSEO.com

Totally Nuked Mods

EZ Communities - Custom PHP/MySQL Scripts and Solutions

RavenNuke(tm) Test site

Codezwiz Your #1 Help Resource

CSE HTML Validator Helped Clean up This Page!

PC Sympathy - Your Source for PC News and Technical Support

Mantis Bugtracker

Nuke-Evolution

TrickedOutNews.com - Home of Tricked Out News Mod, FaceBox and SlimBox RavenNuke(tm) mods