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Dipeptidyl peptidase-4 inhibitors

Drugs & Medication

Dipeptidyl peptidase-4 inhibitors

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GLP-1 and DPP-4 inhibitors
GLP-1 and DPP-4 inhibitors

Dipeptidyl peptidase 4 inhibitors, also DPP-4 inhibitors, are a new class of oral hypoglycemics. Their mechanism of action is thought to result from increased GLP-1,[1][2] which inhibits glucagon release (which increases the blood glucose).

Drugs belonging to this class are vildagliptin and sitagliptin.


  1. ^ Behme MT, Dupre J, McDonald TJ. Glucagon-like peptide 1 improved glycemic control in type 1 diabetes. BMC Endocr Disord. 2003 Apr 10;3(1):3. PMID 12697069. Full Free Text.
  2. ^ Dupre J, Behme MT, Hramiak IM, McFarlane P, Williamson MP, Zabel P, McDonald TJ. Glucagon-like peptide I reduces postprandial glycemic excursions in IDDM. Diabetes. 1995 Jun;44(6):626-30. PMID 7789625.

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