Niche it!
BobbyGs Info
Anticholinesterases

Drugs & Medication

Anticholinesterases

Cyclosarin | Insecticide | Nerve agents | Sarin | Soman | Tabun | VE | VG | VM | VX

From Wikipedia the free encyclopedia, by MultiMedia

Home | Up | Next


Acetylcholinesterase
Acetylcholinesterase

A cholinesterase inhibitor or anticholinesterase is a chemical that inhibits a cholinesterase enzyme from breaking down acetylcholine, so increasing both the level and duration of action of the neurotransmitter acetylcholine.

Contents

Uses

Anticholinesterases occur naturally as venoms and poisons, are used as weapons in the form of nerve agents, and are used medicinally to treat diseases such as myasthenia gravis and Alzheimer's disease, and as an antidote to anticholinergic poisoning. In myasthenia gravis, they are used to increase neuromuscular transmission.

Examples

reversible inhibitor

Compounds which function as reversible competitive or noncompetitive inhibitors of cholinesterase are those most likely to have therapeutic uses. These include:

  • Organophosphates
    • metrifonate
  • Carbamates
    • physostigmine
      neostigmine
      pyridostigmine
      ambenonium
      demarcarium
      rivastigmine
  • Phenanthrine derivatives
    • galantamine
  • Piperidines
    • donepezil, also known as E2020
  • Tacrine, also known as tetrahydroaminoacridine (THA')
  • Edrophonium

quasi-irreversible inhibitor

Compounds which function as quasi-irreversible inhibitors of cholinesterase are those most likely to have use as chemical weapons or pesticides. These include:

  • Organophosphates
  • Carbamates
    • aldicarb
      bendiocarb
      bufencarb
      carbaryl
      carbendazim
      carbetamide
      carbofuran
      chlorbufam
      chloropropham
      ethiofencarb
      formetanate
      methiocarb
      methomyl
      oxamyl
      phenmedipham
      pinmicarb
      pirimicarb
      propamocarb
      propham
      propoxur

Effects

Some major effects of anticholinesterase:

Actions on the autonomic nervous system, that is parasympathetic nervous system will cause bradycardia, hypotension, hypersecretion, bronchoconstriction, GIT hypermotility, and decrease intraocular pressure.

Actions on the neuromuscular junction will result in prolonged muscle contraction.


Home | Up | Anticholinesterases | Choline esters - Acetylcholine | Muscarinic agonists | Nicotinic agonists

Drugs & Medication, made by MultiMedia | Free content and software

This guide is licensed under the GNU Free Documentation License. It uses material from the Wikipedia.


TigerDirect